FIG. 7.

Targeting of human brain tumor transplants after intravenous injection of VSV-p1-GFP. Human glioblastoma cells expressing red fluorescent protein were stereotactically injected into the brains of SCID mice and given 10 days to form sizeable tumors. After a single injection of 10⁷ PFU of VSV-p1-GFP into the tail vein, the virus targeted the tumors, as indicated by GFP fluorescence. (A) Complete spread through the tumor mass at 3 dpi. (B) Initiating focus of viral infection at an early time point (2 dpi). (C) Remote tumor cell clusters were also successfully targeted by VSV-p1-GFP without infecting the surrounding, nontumor brain parenchyma.