Figure 2.

Therapeutic effect of dEpoB and paclitaxel in nude mice bearing MX-1 xenografts after Q2D × 5 6-hr i.v. infusion. Human mammary carcinoma (MX-1) tissue (40 mg) was implanted s.c. into nude mice on day 0. I.v. infusions were given on days 8, 10, 12, 14, and 16. ⋄, control with vehicle only; ○, Taxol 15 mg/kg; ▵, Taxol 24 mg/kg, and ×, dEpoB 30 mg/kg. The average tumor volumes of the control group on days 14, 16, and 18 were 170 ± 10, 246 ± 29, and 345 ± 42 mm³ (mean ± SEM; n = 5), respectively. The vehicle for 6-hr, i.v. infusion was 100 μl of Cremophor/EtOH (1:1) + 3.5 ml of saline solution.