Figure 4.

Therapeutic effect of dEpoB and Taxol in nude mice bearing CCRF-CEM/paclitaxel xenografts after Q2D × 5 6-hr i.v. infusion. Human T cell lymphoblastic leukemia (CCRF-CEM/paclitaxel) cells resistant to Taxol (10⁷ cells) were inoculated s.c. into nude mice on day 0. I.v. infusion was given on days 6, 8, 10, 12, and 14. ⋄, control with vehicle only; □, Taxol 20 mg/kg; and ×, dEpoB 30 mg/kg. The average tumor volumes of the control group on day 12, 14, 16, 18, and 24 were 20 ± 3, 53 ± 6, 77 ± 8, 119 ± 22, and 415 ± 62 mm³, respectively (mean ± SEM; n = 3). The vehicle for 6-hr i.v. infusion was 100 μl of Cremophor/EtOH (1:1) + 3 ml of saline solution.