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Reversed phase-HPLC chromatograph of product ion (m/z 501) experiments. Tracings represent organic-soluble metabolites generated during incubation of UGT1A10 and mutants with UDP-glucuronic acid (4 mM) and 750 μM of each substrate [6-hydroxywarfarin (A), 7-hydroxywarfarin (B), and 8-hydroxywarfarin (C), 10-hydroxywarfarin (D)]. Each substrate was incubated individually for 180 min. All other incubation conditions are noted in Materials and Methods.
