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Product ion (m/z 501) spectra. Each spectrum reflects the organic-soluble metabolites generated during incubation of 750 μM 6-hydroxywarfarin (A), 7-hydroxywafarin (B), or 8-hydroxywarfarin (C) with UGT1A10 or UGT1A10 F90A, F93A, or V92A in the presence of UDP-glucuronic acid (4 mM). Reversed phase-HPLC chromatograph of product ion (m/z 501) experiments. Each substrate was incubated individually for 180 min. All other incubation conditions are noted in Materials and Methods.
