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. Author manuscript; available in PMC: 2010 Jan 27.

Published in final edited form as: Drug Metab Dispos. 2008 Aug 25;36(11):2211–2218. doi: 10.1124/dmd.108.022863

TABLE 3.

Steady-state kinetics for 8-hydroxywarfarin glucuronidation by UGT1A10 and its mutants

Enzyme	Kinetic model	Kinetic Parameters

		V_max	K_m
		nmol/min/mg protein	μM
Wild type	Michaelis-Menten	25 (22–28)^a	390 (240–530)^a
F90A	Michaelis-Menten	18 (15–20)^a	190 (73–310)
V92A	Michaelis-Menten	260 (240–280)^a	390 (300–480)
F93A	Michaelis-Menten	69 (63–75)^a	304 (220–400)

^a

95% confidence intervals.