Table 2.
The baseline scale scores in aripiprazole randomised controlled trials (RCTs) of acute mania.
| Trial | PANSS-total | PANSS-positive | PANSS-negative | PANSS-cognitive | PANSS-hostility | N (efficacy sample) |
|---|---|---|---|---|---|---|
| Aripiprazole | ||||||
| CN138-009 | - | - | - | - | - | 125 |
| CN138-074 | 61.8 ± 16.7 | - | - | - | - | 136 |
| CN138-135 | 62.0 ± 13.7 | - | - | 15.2 ± 3.4 | 10.1 ± 3.4 | 154 |
| CN138-162 | 54.8 ± 10.3 | 16.0 ± 3.9 | 9.6 ± 2.6 | 14.7 ± 3.9 | 9.7 ± 2.6 | 152 |
| CN138-007 | - | - | - | - | - | 267 - |
| CN138008 | - | - | - | - | - | 171 |
| Pooled mean | 59.5 | 16.0 | 9.6 | 14.9 | 9.9 | 1,005 |
| Pooled SD | 13.7 | 3.9 | 2.6 | 3.6 | 3.0 | |
| Placebo | ||||||
| CN138-009 | - | - | - | - | - | 123 |
| CN138-074 | 62.5 ± 16.5 | - | - | - | - | 132 |
| CN138-135 | 63.9 ± 13.1 | - | - | 15.3 ± 3.6 | 10.4 ± 3.6 | 163 |
| CN138-162 | 54.4 ± 10.3 | 16.4 ± 4.9 | 9.4 ± 2.5 | 14.9 ± 3.7 | 9.7 ± 2.5 | 152 |
| CN138-007 | - | - | - | - | - | 134 - |
| CN138008 | ||||||
| Pooled mean | 60.3 | 16.4 | 9.4 | 15.1 | 10.0 | 704 |
| Pooled SD | 13.4 | 4.9 | 2.5 | 3.6 | 3.1 | |
| Comparator | ||||||
| CN138-009 | ||||||
| CN138-074 | ||||||
| CN138-135 | 63.2 ± 12.9 | - | - | 15.6 ± 3.5 | 10.5 ± 3.5 | 155 |
| CN138-162 | 54.1 ± 10.3 | 16.1 ± 3.9 | 9.5 ± 2.5 | 14.6 ± 3.9 | 9.4 ± 2.5 | 161 |
| CN138-007 | ||||||
| CN138008 | - | - | - | - | - | 158 |
| Pooled mean | 58.6 | 16.1 | 9.5 | 15.1 | 9.9 | 474 |
| Pooled SD | 11.6 | 3.9 | 2.5 | 3.7 | 3.0 | |
Dash indicates missing data.
aCalculated from Suppes et al. 2008 [21]; data were not used for the calculation of the pooled mean because there is no data on the change.
PANSS = Positive and Negative Syndrome Scale.