Table 6.
Side effects profile of aripiprazole in comparison to placebo (difference percentage).
| Trial | Target | Overall side effects | Anxiety | Agitation | Acathisia | Constipation | Headache | Hyperprolactinaemia | Insomnia | Nausea | Sedation |
|---|---|---|---|---|---|---|---|---|---|---|---|
| CN138-009 | Mania | 8 | 1 | 9 | 7 | 5 | -6 | 6 | 13 | 15 | |
| CN138-074 | Mania | 6 | 2 | 0.4 | 13.1 | 6.5 | 0.2 | -7 | 5.5 | 9.4 | |
| CN138-135 | Mania | 8 | 4.3 | 0.8 | 9.3 | 6.8 | |||||
| CN138-162 | Mania | 0.1 | 11.4 | 6.8 | 1.8 | 2.1 | 5.4 | ||||
| CN138008 | Mania | 11.4 | 10.9 | 13.7 | |||||||
| CN138-096 | Depression | 11 | 2.9 | 4.7 | 22.7 | -1.5 | -1.1 | 11.5 | 9.8 | 1.3 | |
| CN138-146 | Depression | 6 | 6.5 | 9.3 | 18.6 | 1.6 | -2.3 | 7.7 | 6.6 | 1.1 | |
| CN138-010 | Maintenance | 6 | -14.5 | -10.8 | 6.6 | 7.8 | -19.3 | 4.3 | -7.2 | ||
| CN138-134 | Mania | 8.3 | 13.2 | 5.2 |
Negative results suggest the effect in question was more frequent in the placebo group.