FIG. 8.

Nik-1 tandem HAMP domains. Sequence from the amino-terminal portion of Neurospora crassa Nik-1 is shown. The HAMP and HAMP-like domains and the initial portion of the H-box motif (79) are indicated. Flanking numbers denote positions of the terminal residues within the overall sequence. Numbers within the HD1 and HD2 helices indicate interactions within the HAMP domain (42). Residues at heptad positions a and d are enclosed within boxes, residues at the stutter position a/d are enclosed within a thickly outlined box, and DHp domain invariant His residues are enclosed within a shaded box.