Figure 1.

Alignment of the deduced amino acid sequences of human, frog, and carp prepro-UII. The putative signal peptide sequence is indicated in italics. Conserved amino acid residues are indicated in black. Prohormone convertase cleavage sites are marked by stars. Conserved acidic residues are denoted by a closed circle. The intrachain disulfide bridge in UII is indicated under the urotensin sequence. The amino acid residues are numbered on the right. Gaps, marked by hyphens, have been inserted to achieve optimal alignment.