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. 2010 Jan 25;188(2):181–190. doi: 10.1083/jcb.200908114

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© 2010 Delaval and Doxsey

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — Fibroblasts from PCNT knockout mice show loss of astral microtubules and spindle misorientation. Top (a and c) and side (b and d) views of three-dimensional reconstructed immunofluorescence images of mitotic spindle stained for α-tubulin (green), γ-tubulin (red), and kinetochore (CREST, blue). Mitotic spindles are misoriented in PCNT−/− (b) versus wild-type cells (d). α, metaphase spindle angle relative to the bottom of the dish. Astral microtubules in the wild-type cell (a, arrow) are lost in PCNT−/− cells (b, arrow with broken line). MEF, mouse embryonic fibroblast. Images provided by S. Doxsey and G. Zheng (University of Massachusetts Medical School, Worcester MA).