Table I.
Skin subset | Phenotypes | Frequency |
% | ||
Epidermis | ||
Epidermal LCs | CD207++, CD11bint, CD103−, EpCAM++, CD24+, Sirpα+ | 100 ± 1 |
Dermis | ||
LCs in transit | CD207++, CD11bint, CD103−, EpCAM++, CD24+, Sirpα+ | 6.4 ± 1 |
CD207+ CD103− DDCs | CD207+, CD11blow, CD103−, EpCAM−/low, CD24+, Sirpα− | 2.8 ± 0.5 |
CD207+ CD103+ DDCs | CD207+, CD11blow, CD103+, EpCAM−/low, CD24+, Sirpα− | 2.6 ± 0.6 |
CD207− CD11b− DDCs | CD207−, CD11b−/low, CD103−, EpCAM−, CD24−, Sirpαlow | 16.3 ± 1.3 |
CD207− CD11b+ DDCs | CD207−, CD11bhigh, CD103−, EpCAM−, CD24−, Sirpα+ | 65.8 ± 5 |
CLNs | ||
mLCs | CD207+, CD11b−/low ↓, CD103−, EpCAM+, CD24+, Sirpα+ | 9.5 ± 2.9 |
CD207+ CD103− mDDCs | CD207+, CD11b−/low, CD103−, EpCAM+ ↑, CD24+, Sirpα+ ↑ | 7.0 ± 4.2 |
CD207+ CD103+ mDDCs | CD207+, CD11b−/low, CD103+, EpCAM+ ↑, CD24+, Sirpαlow | 13.5 ± 4.5 |
CD207− CD11b− mDDCs | CD207−, CD11b−, CD103bim ↑, EpCAMbim ↑, CD24bim ↑, Sirpα+ ↑ | 20.8 ± 2.5 |
CD207− CD11b+ mDDCs | CD207−, CD11b+, CD103bim ↑, EpCAMint ↑, CD24int ↑, Sirpα+ | 35.2 ± 2.6 |
The percentage ± SEM of each subset among MHCII+ (epidermis and dermis) or MHCIIhigh CD11cinter-to-high (CLN) cells were calculated from at least six independent experiments. Upward and downward pointing arrows indicate markers that were up-regulated or down-regulated, respectively, upon migration to CLNs. Bim, bimodal.