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. 2010 Jan 18;207(1):77–84. doi: 10.1084/jem.20091097

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© 2010 DeBusk et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — δ-Catenin regulates Rho GTPase activity in a gene dosage sensitive manner. Microvascular endothelial cells isolated from wild-type littermates, δ-catenin heterozygous-null, and homozygous-null mice were analyzed for Rho GTPase activity. Activation of Rac1 and Cdc42 was measured by PAK1-efficient pull-down assays. Precipitated activated Rac1 (A and B) or Cdc42 (C and D) and each total protein from cell lysate were analyzed by Western blot with specific antibody. RhoA activation was pulled down with Rhotekin-agarose beads, analyzed by Western blot, and probed with a RhoA-specific antibody (E and F). *, P < 0.001. Each experiment was repeated three times, and representative images were shown.