Figure 7.

Delayed administration of ATL146e reverses GVHD-associated weight loss successfully. Recipient mice received daily i.p. injections of 1 μg/kg ATL146e or vehicle. Injections were initiated 9 days after HSCT and continued for 14 days. Weights were monitored for 4 weeks, and animals were killed when total weight loss exceeded 25% of starting body weight. Data shown are from one experiment representative of three independent experiments (in all experiments, n=10 mice each for vehicle-treated and ATL146e-treated groups); error bars indicate sem.