Table 3.
Six month outcomes for live donors, by BMI category *
| Outcome | BMI < 25 | 25 ≤ BMI < 30 | 30 ≤ BMI < 35 | BMI ≥ 35 | P |
|---|---|---|---|---|---|
| Primary outcomes (continuous) | |||||
| Change in eGFR (ml/min/1.73m2) | −29.9 ± 0.5 | −30.5 ± 0.5 | −30.9 ± 0.7 | −30.9 ± 1.5 | 0.62 |
| Percent rise in creatinine (%) ** | 41 ± 1 | 43 ± 1 | 44 ± 1 | 43 ± 2 | 0.11 |
| Change in systolic blood pressure (mm Hg) | 0.15 ± 0.45 | −0.62 ± 0.46 | −0.95 ± 0.67 | 0.66 ± 1.24 | 0.40 |
| Change in diastolic blood pressure (mm Hg) | 0.60 ± 0.33 | −0.03 ± 0.34 | −0.40 ± 0.50 | 0.33 ± 0.95 | 0.34 |
| Secondary outcomes (continuous) | |||||
| eGFR (ml/min/1.73m2) | 62.0 ± 0.4 | 59.9 ± 0.4 | 60.6 ± 0.6 | 62.7 ± 1.3 | <0.01 |
| Percent remaining eGFR (%) *** | 70 ± 0.0 | 69 ± 0.0 | 68 ± 0.0 | 68 ± 0.0 | 0.17 |
| Mean serum creatinine (mg/dL) | 1.20 ± 0.01 | 1.28 ± 0.01 | 1.28 ± 0.01 | 1.22 ± 0.02 | <0.01 |
| Systolic blood pressure (mm Hg) | 117.7 ± 0.4 | 121.0 ± 0.4 | 122.6 ± 0.5 | 124.3 ± 1.1 | <0.01 |
| Diastolic blood pressure (mm Hg) | 72.3 ± 0.3 | 74.2 ± 0.3 | 75.2 ± 0.4 | 76.4 ± 0.8 | <0.01 |
| Weight (kg) | 65.2 ± 0.3 | 79.4 ± 0.3 | 90.8 ± 0.5 | 103.6 ± 1.3 | <0.01 |
| Change in weight (kg) | 1.3 ± 0.2 | − 0.0 ± 0.1 | −0.7 ± 0.2 | −3.8 ± 1.4 | <0.01 |
| Secondary outcomes (categorical) | |||||
| Hypertension | 84 (8.2) | 97 (9.4) | 46 (9.3) | 22 (17.2) | 0.01**** |
*
In the cohort of 5304 donors, 3193 (60.2%) had 6-month creatinine values reported, 3011 (56.8%) had weights reported and 2659 (50.1%) had blood pressure values reported. There were no significant differences in missing creatinine, weight or blood pressure across BMI categories.
**
Defined as (rise in creatinine from pre-nephrectomy to 6 months)/(pre-nephrectomy creatinine)
***
Defined as (6 month eGFR)/(Pre-nephrectomy eGFR)
****
When adjusted for pre-nephrectomy hypertension, the increased prevalence of hypertension among very obese donors remained significant (p=0.03).