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Localization of VEGF (a–d) and VEGFR-1 (e, f) mRNA in adult mouse heart. Serial sections from normoxic (a, c, e) and hypoxic (CO-treated) (b, d, f) heart were hybridized in situ with 35S-labeled RNA probes. Shown are dark-field images at a magnification of ×6.25 (a, b, e, f) and bright-field images at a magnification of ×250 (c, d). No signal was observed in control hybridization with sense probes (not shown).
