Figure 3.

Detection of VEGF (a–f), VEGFR-1 (g, h) and VEGFR-2 (i, k) mRNA in adult brain. Sagittal sections through normoxic (a, c, g, i) and hypoxic (CO-treated) (b, d, h, k) mouse brain. VEGF expression in dentate gyrus is indicated by arrowheads. (c) Higher magnification of choroid plexus shown in a. (d) Corresponding hypoxic section. Note down-regulation of VEGF expression in the plexus, while surrounding glial cells show an increased expression. (e) Coronal section through a normoxic olfactory bulb. Note the strong VEGF staining in the glomerular and granule layers. (f) Corresponding hypoxic section. [Magnification: ×6.25 (a, b, and e–k); ×25 (c and d).]