Figure 5.

Localization of VEGF (a–d), VEGFR-1 (e, f) and VEGFR-2 (g, h) mRNA in adult mouse kidney. Dark-field images from sections of normoxic (a, e, g) and hypoxic (CO-treated) (b, f, h) kidneys and bright-field images from normoxic (c) and hypoxic (d) glomeruli are shown. Note the strong VEGF (a, c) staining in glomeruli under normoxic conditions and the intense VEGF expression in the inner medulla during hypoxia (b), while expression in the glomerulus is down-regulated during hypoxia (d). Original magnification: ×6.25 (a, b, e–h); ×250 (c, d).