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. Author manuscript; available in PMC: 2011 Mar 15.

Published in final edited form as: Biochem Pharmacol. 2009 Nov 6;79(6):921–925. doi: 10.1016/j.bcp.2009.10.026

P-gp transport activity was determined as the ATP-dependent uptake of P-gp substrate [³H]-paclitaxel in vesicles prepared from placental brush border membrane (mean ± SEM of 105 individual samples). (A) P-gp-mediated active transport of paclitaxel was significantly greater in homozygotes for the variant 1236T/T genotype than in wild-type (C/C) homozygotes (p = 0.04). (B) Homozygous variants of the 3435T/T genotype displayed significantly greater P-gp transport activity than wild-type (C/C) homozygotes (p = 0.02). (C) G2677T/A variants (A/A, A/T, or T/T) had a trend toward increased P-gp transport activity over wild type homozygotes.

P-gp transport activity was determined as the ATP-dependent uptake of P-gp substrate [³H]-paclitaxel in vesicles prepared from placental brush border membrane (mean ± SEM of 105 individual samples). (A) P-gp-mediated active transport of paclitaxel was significantly greater in homozygotes for the variant 1236T/T genotype than in wild-type (C/C) homozygotes (p = 0.04). (B) Homozygous variants of the 3435T/T genotype displayed significantly greater P-gp transport activity than wild-type (C/C) homozygotes (p = 0.02). (C) G2677T/A variants (A/A, A/T, or T/T) had a trend toward increased P-gp transport activity over wild type homozygotes.