Figure 4. Promotion of muscle differentiation by overexpressed NS is dependent on p53.
(A) Immunostaining of p53−/− myoblasts infected with the empty or the NS-expressing retrovirus. Anti-6xHis tag antibody was used to detect NS. Bar, 10 μm.
(B) Cell proliferation profiles of p53−/− myoblasts infected with the empty or the NS-expressing retrovirus.
(C) Immunostaining of p53−/− myoblasts during differentiation after infection with the empty or the NS-expressing retrovirus. Bar, 40 μm.
(D) Mean + SEM of the ratios between the number of DAPI-positive nuclei in MHC-positive cells and the total number of DAPI-positive nuclei shown in (C). One hundred nuclei were counted in each experiment.
