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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Biochem Pharmacol. 2009 Oct 14;79(5):706–714. doi: 10.1016/j.bcp.2009.10.006

Figure 1. Proteasome function negatively regulates pro-inflammatory IL-6 secretion induced by PV.

Figure 1

ILU-18 cells were either left untreated or pretreated with 0.25μM Aclacinomycin for 2h. At the end of 2h, cells were activated with TNFα (20ng/mL) or Pervanadate (100μM) for 4, 8, or 24 hours and supernatants were collected. Supernatants were analyzed by murine IL-6 ELISA kit per manufacturer’s protocol. Values presented are mean ± standard error from a minimum of three independent experiments and were adjusted for basal (control unstimulated cells) IL-6 secretion (338 pg/mL). Statistically significant differences are denoted by **.