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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Biochem Pharmacol. 2009 Oct 14;79(5):706–714. doi: 10.1016/j.bcp.2009.10.006

Figure 7. To effectively terminate NF-κB activity, proteasome activity must be intact upon PV-stimulation.

Figure 7

ILU-18 cells were treated with Aclacinomycin and PV in the following order: simultaneous addition of Acla & PV (0h); pretreated with Acla followed by PV (−2h); pretreated with PV followed by Acla (+2h); pretreated with PV followed by Acla (+12h); (− and + denote time in hours when Acla addition occurred, before (−) or after (+) addition of PV.) Eighteen hours after the addition of PV (100μM), cells were lysed and analyzed for luciferase activity, as previously described. Data obtained from at least four independent experiments are presented; values are data means ± standard deviation from the mean. Statistically significant differences are denoted by **.