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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Biochem Biophys Res Commun. 2009 Nov 10;391(1):176–181. doi: 10.1016/j.bbrc.2009.11.027

Figure 1. Exogenous HSV-1 can induce filopodia formation.

Figure 1

(A) Increase in the number of filopodia upon exposure to HSV-1 were counted for cells indicated. Counting was done 15–30 min before and after the addition of virus. Numbers are represented as percentages to better compare different cell lines. 3 independent experiments were counted for each cell type (n=25). Numbers of filopodia are presented as means with error bars showing standard deviation. (B) Western Blot analysis confirms activation of Cdc42 at the time points indicated. (C) Down-regulation of Cdc42 inhibits HSV-1 entry. HeLa cells were transfected with siRNA against Cdc42 or control siRNA and exposed to a β-galactosidase expressing HSV-1(KOS) virus.