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. Author manuscript; available in PMC: 2011 Mar 10.
Published in final edited form as: Eur J Pharmacol. 2009 Dec 16;629(1-3):31–39. doi: 10.1016/j.ejphar.2009.12.005

Figure 4. Experiment 3: Spontaneous alternation performance after intraseptal saline or tacrine administration.

Figure 4

Behavioral data (Mean ± SEM) from spontaneous alternation testing for PF (n = 8) and PTD (n = 8) rats after septal infusions of saline or tacrine (5.0, 12.5 ug). Panel A shows that activity on the maze was equal across groups and did not change as a function of drug dose. Panel B shows the overall significant difference between PTD and PF rats in alternation behavior: Regardless of drug condition PF alternated at higher rates than PTD rats (saline: P < 0.001; 5.0 ug: P < 0.01; 12.5 ug: P < 0.01). However, intraseptal infusion of 5.0 ug tacrine did improve alternation rates in the PTD group (P < 0.05).