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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Exp Neurol. 2009 Oct 13;221(1):86–97. doi: 10.1016/j.expneurol.2009.10.005

Figure 6. Axonal terminals of the DG cells are disrupted in the tTA/A53Tα–syn mice.

Figure 6

A–H, Immunostaining of hippocampal sections with antibodies against synapsin (A–D), synaptophysin (E,F) and syntaxin (G,H) at P21 A, B, Low magnification images showing hippocamal CA1, CA2, CA3 areas and the DG. Mossy fibers are axonal terminals of the DG granule cells projecting to CA3. White boxes indicate areas where images in C–H were taken (lower magnification images of E–H are not shown). C–H, High magnification images showing mossy fibers in the striatum-lucidum area stained with synapsin (C,D), synaptophysin (E,F), and syntaxin (G,H) antibodies. tTA/A535α–syn sections (D,F,H) show reduced level of mossy fiber staining compared to littermate controls (C,E,G). Scale bars in A= 100 µm, C=20 µm.