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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Exp Neurol. 2009 Oct 13;221(1):86–97. doi: 10.1016/j.expneurol.2009.10.005

Figure 7. Massive cell loss in the DG caused by α–syn overexpression is detected only during developmental period.

Figure 7

A–D, H & E staining from mice of four different genotypes, nTg (A), A53Tα–syn (B), tTA (C), and tTA/A535α–syn (D). These mice (7-month-old) were not treated with dox, allowing Tg α–syn expression throughout lifetime. E–F, H & E staining from mice that were treated with dox during developmental period (E0.5-P21), and released from dox, thus repressing Tg α–syn only during development and reactivating it after development was completed. No difference was detected between nTg (E) and tTA/A53Tα–syn mice (F) mice. Scale bars in A, E = 50 µm.