Fig. 1.
(A) Rapid-scan absorbance data for the reaction of CYP153A6 with mCPBA at 25 °C, pH = 8.0, P450, 7.1 μM; mCPBA, 150 μM. Selected spectra from 0 to 0.3 s are shown. Inset, data recorded at indicated wavelengths. (B) SVD analysis of the rapid scan data recorded for the reaction in (A). Model used was A→B→C→D with k1 = 91 s-1, k2 = 22. 5 s-1, k3 = 1.5 s-1. A (–○–○–); B (– – –); C (–x–x–); D (--△--△-).
Inset, expansion of data in the visible region. (C) Molar fractions of the different forms of CYP153A6 on the reaction pathway from (B).
