Fig. 2.

Cleavage of pETBlue plasmid DNA by ONOOH. Conditions: 100–120 ng plasmid in 10 µL phosphate buffer, pH 7.4, mixed at ambient temperature with the indicated amounts of peroxynitrite, then run immediately on 0.8% agarose. Upper gel: 0.1 mM added bathocuproin sulfonate (BCS); lower gel: 0.1 mM added Cu(NO3)2. Lane 9 contains the 1 kB DNA ladder.