Figure 1.
5-HT immunostaining rostral and caudal to the T9 lesion site in normal, moderately and severely contused spinal cords (n = 3 per group). Spinal cords were sectioned longitudinally. In uninjured spinal cord, the density of 5-HT in the gray and white matter was similar from rostral to caudal. In the moderately contused spinal cord, the density of 5-HT immunoreactivity was increased rostral to the lesion (* p < 0.05), very much decreased just caudal to the lesion, but further caudally, appears less depleted (* p < 0.05). In the severely contused spinal cord, the density of 5-HT is increased rostral to the lesion (* p < 0.05) and greatly decreased at all levels caudal to the lesion.
