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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Exp Neurol. 2009 Oct 17;221(1):68–78. doi: 10.1016/j.expneurol.2009.10.003

Figure 4.

Figure 4

A) 5-HT2C receptor immunoreactivity in dorsal and ventral horns at L5 from normal, MOD, SEV and TX rats (n=3 per group). In normal and moderately contused rats, cells in dorsal horn and ventral horn show similar levels of immunoreactivity. In SEV rats, dorsal horn and ventral horn cells show increased immunoreactivty. B) Quantification of 5-HT2C receptor immunocytochemistry in dorsal and ventral horns demonstrating significantly increased staining in both dorsal and ventral horn at 15 wks after SEV injury and after TX (* p < 0.05). No such upregulation was found after moderate contusion injury. Data were normalized to VH area fraction of sham injured animals for contusion analysis and to VH area fraction of normal animals for transection analysis. C) Diagram of rodent L5 spinal segment with shaded areas indicating regions of interest collected for analysis.