TABLE 1. Hindlimb activation following drug administration.
Hindlimb activation scores following drug administration to MPD (n=9) and SEV (n=12) rats
| SAL+SAL | SAL+mCPP | DPAT+SAL | DPAT+mCPP | |
|---|---|---|---|---|
| MOD | 0.0±0.0 | 0.2±0.2 | 1.0±0.2* | 0.9±0.3 |
| SEV | 0.0±0.0 | 0.0±0.2 | 1.2±0.0* | 0.4±0.2§ |
mCPP (0.15 mg/kg, IP) did not elicit a significant effect. DPAT (0.1 mg/kg, SC) produced mild hindlimb activation (p < 0.05).
mCPP blocked this DPAT effect in the SEV rats (p < 0.05), but not the MOD rats.