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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Exp Neurol. 2009 Dec 4;221(2):329–334. doi: 10.1016/j.expneurol.2009.11.018

Figure 3. Zonisamide reduces in vivo selegiline binding: Ex vivo measurement of MAO-B activity.

Figure 3

Mice were treated with zonisamide (20 mg/kg i.p.) or vehicle approx. 30 min before selegiline (2.5 mg/kg i.p.) and killed 5.5 h later. Results are the mean MAO-B activity ± SD from mice treated with vehicle (control, n = 9), zonisamide (n=3), selegiline (n=8) or zonisamide plus selegiline (n=8). Analysis of the data by one-way ANOVA with post-hoc testing revealed a significant effect (F3,df3,24 = 157.5) aP<0.001 from control, bp<0.01 vs selegiline group.