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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Exp Neurol. 2009 Dec 4;221(2):329–334. doi: 10.1016/j.expneurol.2009.11.018

Table 1. Zonisamide reduces striatal MPP+ formation.

Treatment Striatal MPP+ (ng/mg tissue) Striatal MPTP (ng/mg tissue)
MPTP 3.1 ± 0.6 0.60 ± 0.09
Zonisamide + MPTP 0.8 ± 0.1a 0.45 ± 0.11

Mice were treated with vehicle or zonisamide (20 mg/kg, i.p.) 15 min before MPTP (30 mg/kg, s.c.) and killed 90 min later. Results are the mean striatal content of MPP+ ± SD (n = 4 mice/group).

a

P<0.005 from group treated with vehicle/MPTP.