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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Exp Neurol. 2009 Dec 4;221(2):329–334. doi: 10.1016/j.expneurol.2009.11.018

Table 2.

Acute zonisamide treatment does not alter DA turnover or GSH content in striata

Control (n=7) Zonisamide (n=3) Selegiline (n=8) Zonisamide + Selegiline (n = 7)
DA
(ng/mg tissue)		 12.9 ± 2.0 13.5 ± 2.0 13.5 ± 2.0 13.4 ± 2.8
DOPAC
(ng/mg tissue)		 1.11 ± 0.27 0.95 ± 0.55 0.98 ± 0.27 1.01 ± 0.31
DOPAC/DA ratio 0.11 ± 0.04 0.07 ± 0.03 0.07 ± 0.03 0.10 ± 0.04
HVA
(ng/mg tissue)		 1.9 ± 0.6 1.7 ± 0.8 1.7 ± 0.4 1.4 ± 0.2
TH
(ng/mg tissue)		 135 ± 24 113 ± 21 152 ± 21 143 ± 29
GSH
(nmol/mg tissue)		 1.23 ± 0.09 1.40 ± 0.11 1.22 ± 0.13 1.22 ± 0.10

Mice were treated with zonisamide (20 mg/kg i.p.) approximately 30 min before selegiline (2.5 mg/kg i.p.) and killed approximately 5.5 h later. Results are the mean ± SD from the number of mice indicated in the table.