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IC50 of complex-specific inhibitors in cortical neurons from old and middle-age rats with and without excess endogenous substrates.
| Complex I (μM) | Complex II (μM) | Complex III (μM) | Complex IV (μM) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | MA | Old | p= | MA | Old | p= | MA | Old | p= | MA | Old | p= |
| Endogenous Substrates | 1.4 | 1.1 | 0.005 | 5.7 | 8.5 | 0.5 | 0.24 | 0.16 | 0.006 | 18 | 12 | 0.002 |
| Exogenous Substrates | 3.0 | 1.0 | 0.02 | 6.1 | 2.1 | 0.9 | 0.13 | 0.052 | 0.0001 | 33 | 26 | 0.5 |
