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. Author manuscript; available in PMC: 2010 Jan 28.

Published in final edited form as: Chembiochem. 2009 May 25;10(8):1344–1347. doi: 10.1002/cbic.200900139

Depsipeptides 1 and 2 reduce cholesteryl ester (CE) levels and fat droplets in the stable transgenic human APP₇₅₁ expressing CHO cell-line 7WD10. a Graph of cellular CE levels as a percent of vehicle treated cells after incubation with 1 () or 2 () for 96 h. Values are plotted as the mean value ± SEM of at least triplicate experiments. (b–d) Fluorescence microscopy of fixed live 7WD10 CHO cells stained with oil red O (red, that stains lipid droplets marked with white arrows) and lysenin (green that stains membrane sphingomyelin) after 48 h culture with b vehicle (0.1 % DMSO in media), c 1 (1 µM) or d 2 (1 µM). Bar = 10 µm.

Inline graphic — Depsipeptides 1 and 2 reduce cholesteryl ester (CE) levels and fat droplets in the stable transgenic human APP₇₅₁ expressing CHO cell-line 7WD10. a Graph of cellular CE levels as a percent of vehicle treated cells after incubation with 1 () or 2 () for 96 h. Values are plotted as the mean value ± SEM of at least triplicate experiments. (b–d) Fluorescence microscopy of fixed live 7WD10 CHO cells stained with oil red O (red, that stains lipid droplets marked with white arrows) and lysenin (green that stains membrane sphingomyelin) after 48 h culture with b vehicle (0.1 % DMSO in media), c 1 (1 µM) or d 2 (1 µM). Bar = 10 µm.