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. 2010 Jan 11;188(1):21–28. doi: 10.1083/jcb.200910096

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© 2010 Follit et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — Effect of Rab8 on the trafficking of the fibrocystin CTS. (A) Flag-tagged Rab8 and Rab8Q67L are localized to cilia of IMCD3 cells, whereas Rab8T22N is not. Insets show the red (Flag) channels of the cilia. Bar, 10 µm. (B) The fibrocystin CTS targets GFP to cilia in control cells and cells expressing wild-type Flag-Rab8 and Flag-Rab8Q67L but not in cells expressing Flag-Rab8T22N. Bar, 2 µm. (C) Quantification of ciliary GFP-CTS fluorescence. Quantification was performed as described in Fig. 1. Error bars indicate SEM. Significance is shown as compared with control: *, P < 0.02; **, P < 0.001.