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. 2010 Jan 11;188(1):83–100. doi: 10.1083/jcb.200906147

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© 2010 van Ree et al.

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Figure 8. — Evidence of numerical chromosome and centriole abnormalities in tumors from UbcH10 transgenic mice. (A) Chromosome counts on lymphoma cells from two UbcH10^T2 transgenic mice. Empty cells in the table indicate that there were no karyotypes with the indicated chromosome number. (B) Interphase FISH for chromosomes 4 and 7 on 5-µm lung tumor sections of UbcH10 transgenic mice. Normal lung sections of wild-type mice were used as controls. The number of FISH signals was determined for 100 interphase cells per lung tumor/normal lung tissue sample. (C) Interphase cells from normal lung tissue of wild-type mice or lung tumors of UbcH10 transgenic mice stained for centrioles (cent.) and DNA. (D) Quantification of centriole numbers in normal lung cells and transgenic lung tumor cells. Bar, 10 µm.