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IC50 values of cytotoxic ribonucleases
| IC50 (µM) | ||
|---|---|---|
| HeLa Cells | ONC | G88R RNase A |
| wild-type | 1.5 ± 0.1 | >50a |
| wild-type dynamin, uninduced | 1.4 ± 0.1 | >50a |
| wild-type dynamin, induced | 1.8 ± 0.2 | >50a |
| K44A dynamin, uninduced | 1.6 ± 0.1 | >50a |
| K44A dynamin, induced | 0.72 ± 0.05 | 17 ± 3 |
A protein concentration of 50 µM resulted in <50% cell death.
