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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Ann Neurol. 2009 Aug;66(2):200–208. doi: 10.1002/ana.21706

Table 2.

Number (%) of subjects with one, mixed, and no (AD or macrocopic infarcts or neocortical Lewy body) pathology with no cognitive impairment, MCI, and probable AD.

Clinical Diagnosis

No cognitive impairment Mild Cognitive Impairment Probable Alzheimer's disease

N=170 N=134 N=179

One pathology 77 (45.3%) 73 (54.5%) 86 (48.0%)

AD path diagnosis 50 (29.4%) 47 (35.1%) 76 (42.4%)
NIA- high 2 (1.2%) 10 (7.5%) 36 (20.1%)
NIA- intermediate 48 (28.2%) 37 (27.6%) 40 (22.3%)

Infarcts 25 (14.7%) 21 (15.7%) 8 (4.5%)

LB 2 (1.2%) 5 (3.7%) 2 (1.1%)

Mixed pathology 16 (9.4%) 26 (19.4%) 82 (45.8%)

AD + Infarcts 13 (7.6%) 23 (17.2%) 54 (30.2%)

AD + LB 2 (1.2%) 3 (2.2%) 19 (10.6%)

AD + Infarcts + LB 0 0 8 (4.5%)

Infarcts + LB 1 (0.6%) 0 1 (0.6%)

No AD, infarcts or LB 77 (45.3%) 35 (26.1%) 11* (6.2%)
*

see text for pathologic diagnoses in those with probable AD without a pathologic diagnosis of AD, macroscopic infarcts or Lewy bodies