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. Author manuscript; available in PMC: 2010 Jan 28.
Published in final edited form as: Neuropsychopharmacology. 2007 Nov 28;33(9):2139–2147. doi: 10.1038/sj.npp.1301623

Figure 2.

Figure 2

Panel (a) illustrates mean (+ SEM) active lever responding for groups tested with various doses of MPEP (Experiment 1). Panel (b) illustrates mean (+ SEM) active lever responding for groups tested with various doses of MTEP (Experiment 3). Both metabotropic glutamate 5 receptor (mGluR5) antagonists dose dependently decreased nicotine seeking. Neither antagonist decreased responding for VS (VS-only group), unless VS-derived reinforcement was inflated by concurrent (2-lever group) or contingent (NIC + VS group) access to nicotine.