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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2009 Sep 29;18(10):2734. doi: 10.1158/1055-9965.EPI-09-0496

Table 4.

Geometric mean serum estradiol (E2) and testosterone (T) concentrations by htSNPs in LD blocks 3 and 4 and common nonsynonomous SNPs in CYP19A1 among cases and controls

RS Number Genotype Estradiol, pmol/L
 Free Estradiol, pmol/L
 Testosterone, nmol/L
 Free testosterone, nmol/L
N Mean (95% CI) P trend N Mean (95% CI) P trend N Mean (95% CI) P trend N Mean (95% CI) P trend
rs749292 GG 683 105.3 (98.0– 113.1) 2.1 × 10−4 681 4.88 (4.48– 5.32) 1.8 × 10−4 1542 17.5 (16.0– 19.3) 0.072 1524 7.90 (7.35– 8.49) 0.015
GA 1047 107.2 (99.9– 115.1) 1046 4.92 (4.55– 5.36) 2341 17.4 (15.8– 19.1) 2304 7.80 (7.28– 8.39)
AA 421 113.0 (104.9– 121.7) 420 5.32 (4.88– 5.80) 917 17.0 (15.4– 18.7) 905 7.63 (7.115– 8.25)
rs6493494 / hCV8234971 GG 695 105.5 (98.2– 113.4) 3.8 × 10−3 692 4.88 (4.48– 5.32) 2.1 × 10−3 1611 17.6 (16.0– 19.3) 0.056 1590 7.90 (7.35– 8.53) 6.7 × 10−3
GA 1043 107.5 (100.2– 115.3) 1042 4.95 (4.55– 5.36) 2307 17.3 (15.8– 19.0) 2273 7.80 (7.25– 8.39)
AA 388 111.6 (103.6– 120.3) 387 5.25 (4.81– 5.73) 846 17.0 (15.4– 18.7) 834 7.63 (7.07– 8.25)
rs1008805 AA 743 109.8 (102.2– 118.0) 3.3 × 10−3 742 5.14 (4.70– 5.58) 3.1 × 10−3 1602 17.1 (15.6– 18.8) 0.089 1581 7.73 (7.18– 8.32) 0.011
GA 1041 106.8 (99.42– 114.7) 1040 4.92 (4.51– 5.32) 2351 17.6 (16.1– 19.4) 2316 7.94 (7.35– 8.53)
GG 356 104.1 (96.5– 112.3) 353 4.84 (4.40– 5.28) 841 17.5 (15.9– 19.3) 830 7.94 (7.38– 8.56)
rs727479 AA 916 110.5 (103.0– 118.6) 1.2 × 10−5 913 5.14 (4.70– 5.58) 1.9 × 10−4 2025 17.1 (15.5– 18.7) 0.037 1996 7.63 (7.07– 8.22) 1.8 × 10−4
AC 950 107.3 (100.0– 115.3) 949 4.95 (4.55– 5.39) 2175 17.4 (15.8– 19.1) 2145 7.90 (7.35– 8.52)
CC 267 100.8 (93.3– 108.9) 266 4.66 (4.26– 5.14) 587 17.7 (16.0– 19.5) 579 7.94 (7.35– 8.60)
rs2414096 AA 537 110.0 (102.2– 118.4) 0.066 534 5.10 (4.70– 5.58) 0.094 1218 17.2 (15.6– 18.9) 0.32 1198 7.63 (7.07– 8.22) 7.7 × 10−3
GA 1088 107.1 (99.8– 114.9) 1087 4.95 (4.55– 5.36) 2404 17.3 (15.7– 19.0) 2373 7.84 (7.28– 8.42)
GG 523 106.4 (98.9– 114.5) 522 4.92 (4.51– 5.39) 1179 17.5 (15.9– 19.2) 1164 7.90 (7.35– 8.53)
rs28757184 / Thr201Met GG 1985 107.8 (100.6– 115.5) 0.10 1981 4.99 (4.59– 5.43) 0.055 4426 17.3 (15.8– 19.0) 0.17 4362 7.80 (7.25– 8.39) 0.16
GA 137 102.0 (93.7– 111.0) - 137 4.59 (4.15– 5.10) 329 17.9 (16.1– 19.8) 326 7.94 (7.32– 8.60)
AA 3 135.8 (96.7– 190.5) - 3 7.67 (5.10– 11.49) 5 18.4 (12.7– 26.6) 5 10.37 (7.77– 13.80)
rs700519/Arg264Cys GG 2000 107.5 (100.2– 115.3) 0.60 1995 4.99 (4.59– 5.39) 0.55 4438 17.5 (15.9– 19.2) 0.13 4374 7.87 (7.32– 8.46) 0.079
GA 151 108.1 (99.8– 117.1) 151 4.99 (4.51– 5.47) 283 16.8 (15.2– 18.6) 282 7.59 (7.00– 8.22)
AA 3 67.5 (48.0– 95.0) 3 3.19 (2.13– 4.77) 22 17.1 (14.0– 20.7) 21 7.73 (6.62– 9.01)
rs17601241 GG 1799 107.0 (99.8– 114.8) 0.042 1795 4.95 (4.55– 5.36) 0.044 4006 17.4 (15.8– 19.1) 0.22 3950 7.80 (7.28– 8.42) 0.22
GA 356 110.2 (102.2– 118.8) 356 5.10 (4.66– 5.58) 786 17.2 (15.6– 18.9) 779 7.73 (7.18– 8.36)
AA 16 117.0 (997– 137.3) 16 5.65 (4.70– 6.86) 37 16.1 (13.7– 18.8) 35 7.25 (6.38– 8.25)
rs10046 AA 572 111.5 (103.7– 120.0) 5.7 × 10−3 569 5.21 (4.77– 5.65) 0.014 1300 17.2 (15.6– 18.9) 0.45 1279 7.70 (7.14– 8.29) 0.033
GA 1070 106.5 (99.3– 114.3) 1069 4.92 (4.51– 5.36) 2380 17.3 (15.8– 19.0) 2347 7.80 (7.28– 8.42)
GG 485 106.3 (98.8– 114.4) 484 4.95 (4.51– 5.39) 1082 17.4 (15.8– 19.1) 1070 7.90 (7.35– 8.53)
rs4646 CC 1113 107.4 (100.0– 115.2) 0.930 1110 4.95 (4.55– 5.39) 0.46 2567 17.3 (15.8– 19.0) 0.88 2531 7.77 (7.21– 8.36) 0.51
AC 850 107.7 (100.2– 115.8) 849 5.03 (4.62– 5.47) 1870 17.2 (15.7– 18.9) 1842 7.80 (7.25– 8.39)
AA 171 107.2 (98.8– 116.4) 171 4.99 (4.51– 5.51) 363 17.4 (15.7– 19.2) 360 7.87 (7.25– 8.53)