Table 5.
Estradiol and testosterone concentrations* by haplotype A-A (rs749292-rs727479)
| Number of copies of A-A haplotype |
P trend | |||
|---|---|---|---|---|
| 0 | 1 | 2 | ||
| Estradiol | ||||
| N | 698 | 1088 | 427 | 1×10−5 |
| Mean | 109.5 | 113.6 | 119.3 | |
| (95% CI) | (57.3– 209.2) | (60.1– 214.7) | (61.7– 230.6) | |
| Free estradiol | ||||
| N | 696 | 1086 | 425 | 6.6×10−5 |
| Mean | 1.45 | 1.55 | 1.66 | |
| (95% CI) | (0.46–4.55) | (0.51–4.71) | (0.55–4.97) | |
| Testosterone | ||||
| N | 1573 | 2423 | 929 | 0.099 |
| Mean | 16.2 | 16.0 | 15.7 | |
| (95% CI) | (7.4– 35.5) | (7.2– 35.7) | (6.9– 35.4) | |
| Free testosterone | ||||
| N | 1555 | 2385 | 918 | 0.020 |
| Mean | 2.29 | 2.32 | 2.26 | |
| (95% CI) | (0.97–5.39) | (1.01–5.3) | (0.96–5.29) | |
| Free testosterone/ free estradiol ratio | ||||
| N | 690 | 1080 | 423 | 8×10−6 |
| Mean | 0.67 | 0.69 | 0.74 | |
| (95% CI) | (0.30–1.48) | (0.31–1.53) | (0.33–1.67) | |
*
Hormone values are geometric means and 95% confidence intervals.