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. Author manuscript; available in PMC: 2010 Jan 28.
Published in final edited form as: Exp Biol Med (Maywood). 2006 Mar;231(3):328. doi: 10.1177/153537020623100314

Figure 1.

Figure 1

Δεsil β-YAC transgene construct used for the production of transgenic mice. A diagram of the human β-globin locus is shown on the top of the panel. The expanded diagram below depicts the proximal and distal region of the ε-globin gene promoter with the regulatory motifs labeled as follows: the minimal promoter, GATA-1 sites at positions −165 and −208, two overlapping motifs for YY1 and GATA-1 at position −269, and CACC box at position −379. The deletion of the ε-globin silencer region between −406 bp to −182 bp upstream of the cap site (filled arrow) is shown below the ε-globin promoter diagram. The deletion includes the CACC box at position −379.