Table 1.

Enzyme Inhibitory and Antiviral Activity of Inhibitors 3a–m

Entry	Inhibitor	Ki (nM)	IC50 (nM)a
1		0.15 ± 0.019	ndb
2		0.16 ± 0.04	30 ± 1
3		0.16 ± 0.011	nd
4		0.026 ± 0.012	4.9 ± 0.3
5		0.81 ± 0.12	nd
6		0.74 ± 0.15	nd
7		27 ± 0.81	nd
8		0.041 ± 0.002	3.4 ± 0.7
9		16 ± 2.2	nd
10		33 ± 1.9	nd
11		6.3 ± 0.57	>1000
12		1.9 ± 0.2	>1000
13		19 ± 0.76	>1000
SQVc	-	-	16 ± 3
APVd	-	-	27 ± 6

^aMT-2 human T-lymphoid cells exposed to HIV-1_LAI

^bnd = not determined

^cSQV = saquinavir

^dAPV = amprenavir.