Structures of haloduracin, lacticin 3147, nisin, and mersacidin. Shaded circles of Halα indicate residues that were mutated in this study (Glu22, Cys23, and Cys27). Ala-S-Ala represents lanthionine, Abu-S-Ala represents methyllanthionine, and OBu represents 2-oxobutyryl.