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. 2009 Aug 13;4(10):865–874. doi: 10.1021/cb900194x

Table 1. Comparison of haloduracin and nisin activities.

Specific activity of haloduracin and nisin assessed by liquid growth inhibition assay
    Haloduracin
 Nisin
Strain Source IC50 (nM) MIC (nM) IC50 (nM) MIC (nM)
Lactococcus lactis HP ATCCa 11602 29 ± 21 73.4 14 ± 5 32.2
Lactococcus lactis 481 CNRZb 481 63 ± 24 195 68 ± 6 127
Lactococcus lactis 11454 ATCC 11454 308 ± 13 625 1,759 ± 400 2,800
Vancomycin-resistant Enterococcus faecium C33105c 265 ± 15 781 4,953 ± 187 12,500
Bacillus anthracis Sterne 7702 Gut et al.d 363 ± 54 677 311 ± 216 417
Bacillus subtilis ATCC 6633 262 ± 54 469 414 ± 165 820
methicillin-resistant Staphylococcus aureus C5c 2,616 ± 396 4,690 1,459 ± 7 1,560
Staphylococcus aureus ATCC 12600 1,144 ± 290 1,560 2,205 ± 523 4,690
Staphylococcus epidermidis 15X Ekkelenkamp et al.e 273 ± 23 313 368 ± 152 508
Micrococcus luteus ATCC 4698 520 ± 17 1,250 266 ± 92 410
Streptococcus mutans ATCC 25175 1,837 ± 417 2,500 5,394 ± 732 12,500
Activity assessed by agar diffusion growth inhibition assay
Strain Source Haloduracin Nisin
Lactococcus lactis 117 CNRZ 117 + +
Bacillus subtilis DB104 Kawamura et al.f + +
Bacillus subtilis LH45 Liu et al.g + +
Bacillus cereus Z4222 INRAh Z4222 + +
Bacillus cereus TZ415 INRA TZ415 + +
Enterobacter cloacae 10-19C ATCC 29893 − −
Escherichia coli DH5α UIUC-CMFi − −
a

ATCC: American type Culture Collection.

b

CNRZ: National Centre for Zootechnical Research.

c

Clinical isolates from Carle Foundation Hospital (Urbana, IL).

d

Reference (17).

e

Reference (43).

f

Reference (44).

g

Reference (45).

h

INRA: Institut National de la Recherche Agronomique.

i

UIUC-CMF: University of Illinois Urbana-Champaign Cell and Media Facility.