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Effect of GyrA on antibiotic susceptibility of strain SPC105
| Treatment (μM) | Relative survival (%)a |
||
|---|---|---|---|
| No plasmid | pSPOK-gyrA | pDrive-gyrA | |
| No treatment | 100 | 96 | 98 |
| Nalidixic acid | |||
| 100 | 55 | 57 | 15 |
| 300 | 30 | 56 | NT |
| 400 | 8 | 33 | NT |
| Norfloxacin | |||
| 0.5 | 64 | 82 | 3 |
| 1.25 | 20 | 51 | NT |
| 1.5 | 5 | 13 | NT |
| Chloramphenicol | |||
| 7 | 88 | 100 | 45 |
| 42 | 48 | 100 | NT |
| 70 | 28 | 75 | NT |
| Tetracycline | |||
| 1 | 90 | 100 | 37 |
| 2 | 53 | 100 | NT |
| 6 | 14 | 50 | NT |
NT, not tested. pSPOK-gyrA, overexpression of GyrA; pDrive-gyrA, reduced expression of GyrA.
