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Heart rate response of a female rhesus macaque to oral treatment with Org 9935 200 mg/kg once/day (200 qd), 200 mg/kg twice/day (200 BID), and 400 mg/kg once/day (400 qd). Arrows indicate drug dosing. Note normal variations in daily heart rate in untreated animals, and that heart rate returns to pre-treatment levels following discontinuation of treatment.
