Table 3.
Structural differences between tyrosyl-tRNA synthetases from human & P. falciparum
| Hs-TyrRS (2PID)* | Pf-TyrRS(PF11_0181)@ | Hs-TyrRS (1N3L)! | Pf-TyrRS (MAL8P1.125)$ | |
|---|---|---|---|---|
| Motif 1 | HVGH | HLGN | HAVY | HIAQ |
| Motif 2 | KLGKS | KYSKS | KMSSS | KMSKS |
| Residues involved in tyrosine and A73 recognition | Ser200 | Arg229 | Gly46 | Gly67 |
| Gln202 | Glu231 | Arg93 | Val116 | |
| Met252 | Gln279 | Ala340 | Lys370 | |
| Ile274 | Leu301 | Tyr341 | Val371 | |
| Insertions | ---- | Arg157-Glu175 | ||
| ---- | Glu316-Leu321 | Met104-Ser107 | Glu142-Lys146 | |
| ---- | Asn369-Lys422 | Asn356-Lys360 |
* human mitochondrial
@ P. falciparum bacteria-like
! human cytosolic
$ P. falciparum human-like